Due Date form Ultrasound Report. Minor/Significance Unknown. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Pregnancy: Risk Summary-Clinical Considerations. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. This may be helped by giving the medication more slowly or at a lower dose. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Use Caution/Monitor. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Dosing: (a) Divide calculated total cumulate dose . Applies only to oral form of both agents. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. however iron sucrose requires multiple small intermittent doses over days to weeks. US residents can call their local poison control center at 1-800-222-1222. Modify Therapy/Monitor Closely. Dosage Calculator in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Interaction only with oral iron administration. Applies only to oral form of both agents. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Minor/Significance Unknown. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Intravenous iron sucrose: establishing a safe dose - PubMed iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. One dose IV Iron replacement | Monoferric Applies only to oral form of both agents. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Medicinal forms Deferasirox chelates iron. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Venofer Dosing and Administration Copyright 1993-2021 Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Intravenous iron therapy for patients with anemia IV iron products (adults) - UpToDate Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Minor/Significance Unknown. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Iron Deficiency Calculator - MDApp All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Separate by 2 hr. Do not administer Venofer to patients with evidence of iron overload. 1995 Mar-Apr;11(2):163-8. Applies only to oral form of both agents. Applies only to oral form of both agents. Assessing new treatment options. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. This information is not individual medical advice and does not substitute for the advice of your health care professional. Oral and parenteral products - see background option for oral products. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. These can be input in g/dL, g/L or mmol/L. Use Caution/Monitor. Adding plans allows you to compare formulary status to other drugs in the same class. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. 2. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. . Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Feraheme does not contain antimicrobial preservatives. Use Caution/Monitor. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Use Caution/Monitor. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. 2010;18(3). Minor/Significance Unknown. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. PDF Venofer - Food and Drug Administration All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Use Caution/Monitor. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. I. Venofer treatment may be repeated if iron deficiency reoccurs. Use Caution/Monitor. Anemia; 2015: 763576. Kumpf VJ. Avoid or Use Alternate Drug. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Consult your doctor before breast-feeding. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Applies only to oral form of both agents. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Intravenous iron-dextran: therapeutic and experimental possibilities. 4. Nutr Clin Pract. ]Venofer treatment may be repeated if iron deficiency reoccurs. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Applies only to oral form of both agents. In the text below the tool there is more information on how the iron deficit is calculated. commonly, these are "non-preferred" brand drugs or specialty The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Parenteral iron dextran therapy. 2015: 763576. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Dosing and Infusion Rates - PRIVIGEN Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Minor/Significance Unknown. https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Contraindicated. Steps on how to print your input & results: 1. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Applies only to oral form of both agents. Creating an account is free and takes less than 1 minute. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Contact the applicable plan In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Ganzoni AM. 1970; 100(7):301-3. No data are available regarding overdosage of Venofer in humans. Copyright 1993-2021 Uses for Iron Sucrose Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Schrier SL, Mentzer WC, Landaw SA. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor/Significance Unknown. Avoid or Use Alternate Drug. Applies only to oral form of both agents. 1998 Feb;25(1):65-8. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Applies only to oral form of both agents. Hollands J, Foote E, Rodriguez A. 1988 May;111(5):566-70. Applies only to oral form of both agents. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Intravenous iron sucrose for children with iron deficiency failing to Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Applies only to oral form of both agents. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Accessed: 4/12/2011. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Minor (1)iron sucrose, benazepril. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Avoid or Use Alternate Drug. For additional Safety Information, please see Full Prescribing Information. A healthcare provider will give you this injection. [. Applies only to oral form of both agents. Applies only to oral form of both agents. *Administer early during the dialysis session. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Last updated on Jun 1, 2022. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. commonly, these are "preferred" (on formulary) brand drugs. Applies only to oral form of both agents. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Minor/Significance Unknown. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Diagnosis and management of iron deficiency anaemia: a clinical update. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Below the form there are further instructions on how to use the calculator. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . DICP. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Applies only to oral form of both agents. 1970;100(7):301303. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Do not double the dose to catch up. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Official Journal of the International Society of Nephrology. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Perinatology and Obstetrical Calculators Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. 5. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. informational and educational purposes only. Applies only to oral form of both agents. Included in the iron dextran package insert. Minor/Significance Unknown. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Learn how to store and discard medical supplies safely. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Am J Kid Dis 2001; 38 988991. Iron sucrose: 20 mg/mL. The dosage of Venofer is expressed in mg of elemental iron. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Found in multiple references. May increase risk of hypotension. Chandler G, Harchowel J, Macdougall I. Applies only to oral form of both agents. Use Caution/Monitor. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? The primary endpoint was the proportion of patients with . By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Use Caution/Monitor. 1 Dosing for patients who weigh less than 50 kg Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Applies only to oral form of both agents. Share cases and questions with Physicians on Medscape consult. Calculosaurus | Ferinject dose calculator Slow or stop the infusion if adverse reactions occur. Venofer is given as an infusion into a vein. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. This website also contains material copyrighted by 3rd parties. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. The recipient will receive more details and instructions to access this offer. Applies only to oral form of both agents. Iron Product. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). 1) Ganzoni AM. Applies only to oral form of both agents. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. PDF Treatment Guideline - Gloucestershire Royal Hospital Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor. Corrected Calcium. Avoid or Use Alternate Drug. Human studies not conducted. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Minor/Significance Unknown. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Jacobs P, Dommisse J. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. David McAuley, Pharm.D. Drug Des Devel Ther; 5: 5160. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete.
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